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  • br Hancks D C A role for retrotransposons in

    2020-08-28


    Hancks, D.C., 2018. A role for retrotransposons in chromothripsis. Methods Mol.
    Khan, H., Smit, A., Boissinot, S., 2006. Molecular evolution and tempo of amplifi-cation of human LINE-1 retrotransposons since the origin of primates. Genome Res. 16, 78e87.
    Koplev, S., Lin, K., Dohlman, A.B., Ma’ayan, A., 2018. Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition. PLoS Comput. Biol. 14 e1005911.
    Please cite this article as: Bacolla, A et al., Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction, Progress in Biophysics and Molecular Biology, https://doi.org/10.1016/j.pbiomolbio.2019.03.004
    14 A. Bacolla et al. / Progress in Biophysics and Molecular Biology xxx (xxxx) xxx
    Macheret, M., Halazonetis, T.D., 2015. DNA replication stress as a hallmark of cancer.
    Minakshi, R., Rahman, S., Jan, A.T., Archana, A., Kim, J., 2017. Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer. Exp. Mol. Med. 49, e389. Miyamoto, Y., Kitamura, N., Nakamura, Y., Futamura, M., Miyamoto, T., Yoshida, M., Ono, M., Ichinose, S., Arakawa, H., 2011. Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control. PLoS One 6, e16054.
    Rambo, R.P., Tainer, J.A., 2010. Bridging the solution divide: comprehensive struc-tural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering. Curr. Opin. Struct. Biol. 20, 128e137.
    mutagenic RAD52 and POLtheta pathways. Elife 7.
    Turrens, J.F., 2003. Mitochondrial formation of reactive oxygen species. J. Physiol.
    Vogt, J., Bengesser, K., Claes, K.B., Wimmer, K., Mautner, V.F., van Minkelen, R., Legius, E., Brems, H., Upadhyaya, M., Hogel, J., Lazaro, C., Rosenbaum, T., Bammert, S., Messiaen, L., Cooper, D.N., Kehrer-Sawatzki, H., 2014. SVA retro-transposon insertion-associated 62996-74-1 represents a novel mutational mech-anism underlying large genomic copy number changes with non-recurrent breakpoints. Genome Biol. 15, R80.
    Wang, G., Vasquez, K.M., 2017. Effects of replication and transcription on DNA structure-related genetic instability. Genes 8.
    Please cite this article as: Bacolla, A et al., Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction, Progress in Biophysics and Molecular Biology, https://doi.org/10.1016/j.pbiomolbio.2019.03.004
    A. Bacolla et al. / Progress in Biophysics and Molecular Biology xxx (xxxx) xxx 15
    Please cite this article as: Bacolla, A et al., Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction, Progress in Biophysics and Molecular Biology, https://doi.org/10.1016/j.pbiomolbio.2019.03.004  THE JOURNAL OF PEDIATRICS • www.jpeds.com  ORIGINAL
    ARTICLES
    Cancer Prevention Education for Providers, Staff, Parents, and Teens Improves Adolescent Human Papillomavirus Immunization Rates
    Manika Suryadevara, MD1, Cynthia A. Bonville, MS1, Donald A. Cibula, PhD2, and Joseph B. Domachowske, MD1
    Objective To develop a program to educate providers, office staff, patients, and parents on life-long cancer pre-vention strategies, including the use of human papillomavirus (HPV) vaccine to improve adolescent HPV vaccina-tion rates.
    Study design A 2-phase program was implemented at 6 pediatric practices across upstate New York. Phase 1 included provider and staff education regarding practice-specific vaccination challenges and discussion of the con-tents of a study-specific cancer-prevention booklet, which included HPV vaccine information. Throughout phase 2, the booklets were distributed to all adolescents and their parents during office visits over a 12-month period. Practice-specific, countywide, and statewide HPV vaccination rates were assessed before phase 1, and 6 and 12 months after the launch of phase 2.
    Results One year after implementing phase 2 in 6 practices, adolescent HPV vaccine series initiation increased by at least 10% in 3 practices, and at least 5% in 5 practices. Similarly, adolescent vaccine series completion rates increased by more than 10% in 3 practices. The percent change in vaccine series completion rates across all study sites postintervention ranged from 12% to 20% for 11- to 12-year-olds, and from 7% to 23% for 13- to 18-year-olds. Conclusions Cancer prevention education targeting providers, office staff, patients, and parents was modestly effective for improving adolescent HPV vaccination rates. (J Pediatr 2019;205:145-52).