• br Conclusions br Author contributions br Declarations

  2019-08-11

  

  Conclusions Author contributions Declarations of interest Acknowledgments The Radiation Effects Research Foundation (RERF), Hiroshima and Nagasaki, Japan is a public interest foundation funded by the Japanese Ministry of Health, Labour and Welfare (MHLW) and the US Department of Energy (

• br Epigenetic regulation of astrocyte development and functi

  2019-07-30

  

  Epigenetic regulation of astrocyte development and function Conclusion The extent of astrocyte involvement in the development and progression of neurodegenerative diseases is an active area of investigation, particularly following the development of new tools and understanding of reactive astr

• Rats were made hyperammonemic by feeding them

  2019-07-30

  

  Rats were made hyperammonemic by feeding them and ammonium-containing diet [40]. Membrane expression, phosphorylation of the GluA1 and GluA2 subunits and the mechanisms underlying their alterations in hyperammonemic rats were analyzed in freshly isolated cerebellar slices. Material & methods R

• br Transparency document br Introduction The high mortality

  2019-07-24

  

  Transparency document Introduction The high mortality rate of breast cancer (BCa) is mainly due to tumor cell dissemination from the primary lesion, leading to metastatic disease [1]. Metastasis is largely driven by the activity of chemokines, which are chemo-attracting small cytokine molecule

• br Transparency document br Acknowledgements Own research

  2019-07-08

  

  Transparency document Acknowledgements Own research included in this review article was funded by the University Hospital Frankfurt, Frankfurt am Main, Germany and grants of the German Research Foundation (DFG) (CH 806/1-1). Introduction Cholangiocarcinoma (CCA) is the most common biliary

• br Materials and methods br

  2019-07-08

  

  Materials and methods Results Discussion In this study, we demonstrate that SIRT1-mediated deacetylation is required for IPO to activate the Akt signaling pathway to confer cardioprotection. Reduced SIRT1 and increased Akt acetylation are responsible for the loss of IPO-mediated cardioprote

• Variations in DNA repair genes seem to be

  2019-07-06

  

  Variations in DNA repair genes seem to be related to cancer risk; in particular, some studies reported the association between genes in the Omadacycline structure excision repair (BER) pathway, such as 8-oxoguanine DNA glycosylase (OGG1) and apurinic/apyrimidinic endonuclease (APE1/APEX1), and risk

• Important efforts were made during the

  2019-07-06

  

  Important efforts were made during the last decades in order to better understand the key pathogenic features of DR and DN, so that new and more effective therapies and preventative strategies might be developed [[7], [8], [9]]. Despite these, the multifactorial intervention strategies aimed to decr

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