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br Functional limitations secondary to comorbid conditions
2020-08-07
Functional limitations secondary to comorbid conditions were com-mon among study participants. For some, difficulty with activities of daily living (bathing, dressing) prohibited participation in any physical activity, including walking. Gait and balance issues limited mobility and ambulation f
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br In silico transcription factor binding site prediction br
2020-08-06
3.5. In-silico transcription factor binding site prediction TFBS analysis by PROMO predicted that the presence of minor at both loci results in gain of Pax-5 and p53 binding sites. While AP-2alphaA binding site was lost for rs2276201and for rs9347683 C/ EBPbeta, NF-1 and ENKTF-1 binding sites w
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GW311616 br Conclusion br Lymphadenectomy may have a
2020-08-06
Conclusion Lymphadenectomy may have a therapeutic value and be significantly associated with im-proved survival in advanced stage ovarian cancer patients. The effect of lymphadenectomy on PFS was only found in patients with early stage and advanced stage disease with >10 GW311616 node removed.
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br In summary we provide evidence
2020-08-04
In summary, we provide evidence of the inhibitory effect of aspirin on the stemness of human lung cancer UNC1999 and demonstrate that as-pirin impedes the exosome secretion and malignant paracrine effect of these cells. Fig. 7. Synergistic effect of aspirin and cisplatin on lung cancer cells.
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br Corresponding author at Laboratory of Biochemistry and
2020-08-03
Corresponding author at: Laboratory of Biochemistry and Biomedical Materials, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, PR China. E-mail address: [email protected] (B. Han). angiogenesis drugs may contribute to the treatment and prognosis of gastric cancer.
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Hexa His tag peptide br INTRODUCTION br Kinases and phosphat
2020-07-28
INTRODUCTION Kinases and phosphatases control the reversible process of phosphorylation. Signaling networks involving these enzymes compute extracellular signals into transcriptional, functional, and phenotypical responses. Deregulation of signaling networks can lead to the initiation and
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br Subhash VV Tan SH Tan WL
2020-07-28
36. Subhash VV, Tan SH, Tan WL, et al. GTSE1 expression re-presses apoptotic signaling and confers cisplatin resistance in gastric cancer cells. BMC Cancer. 2015;15:550. 37. Chen F, Jin X, Zhao J, Gou S. DN604: a platinum(II) drug candidate with classic SAR can induce apoptosis via suppressing
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br The most important objective of the different pro tocols
2020-07-28
The most important objective of the different pro-tocols has been to achieve maximum likelihood of detecting metastases. Extending the distance between steps in the sectioning protocol was undertaken so that the previously neglected part of broad lymph nodes was then assessed. In a prelimina
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br Several limitations identified in this study include we
2020-07-27
Several limitations identified in this P 22077 study, include: (1) we were unable to ascertain which resources are most popular and most frequently visited by caregivers, (2) we did not have context on which resources are currently recommended by physicians, (3) we did not have context on the res
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br The abdominal wall is a common metastatic
2020-07-26
The abdominal wall is a common metastatic site for abdominal malignant tumors including liver cancer, gastric cancer, and colon and rectal cancer. It is difficult to repair and reconstruct abdominal wall defects resulting from resection of abdominal wall tumors. The devel-opment of biological patc
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br Introduction br Heat Shock Protein HSP
2020-07-26
1. Introduction Heat Shock Protein 90 (HSP90), an ATP dependent molecular cha-perone, has been categorized as a crucial facilitator of oncogene addiction and cancer cell survival [1]. A chaperone protein acts as a cellular machine responsible for correct folding and maturation of its client pro
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br In vivo experiments br Male
2020-07-04
2.6. In vivo experiments Male severe combined immune deficiency (SCID) mice (Lab Animal Shared Resource at RPCCC), or Hsd:Athymic Nude-Fox1nu nude mice (Envigo, Indianapolis, IN), were purchased at 5 weeks of age, and ex-perimental procedures were initiated when mice were 6 weeks old. Mice were
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br Impact of Adjuvant Chemotherapy on PD L Expression br
2020-03-24
Impact of Adjuvant Chemotherapy on PD-L1 Expression infection.4 Interaction of PD-L1 on the tumor AWD 131-138 with PD-1 on T-cells abrogates T-cell function and prevents the immune system from attacking the tumor cells, resulting in tumor cell proliferation and immune escape.5 However, blocking
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Biochemical Pharmacology br Calcein AM
2020-03-24
Biochemical Pharmacology 159 (2019) 52–63 2.9. Calcein AM exclusion assay For calcein AM exclusion assays, MDA-MB-231 shRNA-ACSL4, MDA-MB-231 mock (in the presence or absence of 1 µM triacsin C), MCF-7 Tet-Off/ACSL4 and MCF-7 Tet-Off empty vector Tirapazamine (2 × 106) were incubated in DMEM
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br Jagsi R Hawley ST Griffith KA
2020-03-24
20. Jagsi R, Hawley ST, Griffith KA, et al. Contralateral prophylactic mastectomy decisions in SC 560 population-based sample of patients with early-stage breast cancer. JAMA Surg. 2017;152:274e282. 21. Storm-Dickerson T, Das L, Gabriel A, Gitlin M, Farias J, Macarios D. What drives patient cho