• The proportion of patients developing

  2019-08-26

  

  The proportion of patients developing a severe irAE in this series was low (8.4%) and there were no treatment related deaths. Furthermore, only 8 patients required overnight hospitalization (of whom 1 required admission to an intensive care unit) to treat irAE. The pattern of irAE was, on the whole,

• Safety profile of the combination treatment resulted good

  2019-08-26

  

  Safety profile of the combination treatment resulted good and toxicities easily manageable in both treatment groups. The weekly access to the clinic for T1 patients can reasonably explain the higher number of any grade adverse events observed in this Thonzonium Bromide treatment group, with an over

• The average mutation frequency in pre

  2019-08-26

  

  The average mutation frequency in pre-op ctDNA was lower than that in tDNA, and there were less gene mutations in pre-op ctDNA than in tDNA. Additionally, there were discordant tDNA -pre-op ctDNA gene mutations in 33 sample pairs. This may be caused by lung cancer heterogeneity and the sensitivity o

• Nonetheless questions remain For example why do

  2019-08-26

  

  Nonetheless, questions remain. For example, why do PTEN-mutated ADC L-Glutamine not always transform into SCC? Given that little is known about the discovery rate of co-developed activating EGFR mutations and PTEN deletions in the same tumor (Fig. A6 in Supplementary material), we used our observat

• The size of the bias depends on

  2019-08-16

  

  The size of the bias depends on the proportion of patients excluded by non-consent and by how this selection influences this group, which will vary with each registry. Thus, in an observational study of breast cancer in the UK, it was demonstrated that the use of the dataset requiring consent omitte

• In England cancer surveillance statistics are published

  2019-08-16

  

  In England, cancer surveillance statistics L-Glutamine published on Public Health England’s ‘CancerData’ dashboard for each of the 209 local healthcare commissioning bodies (Clinical Commissioning Groups – CCGs) [7]. These include the percentage of patients diagnosed with localised tumours (TNM Stag

• br Conclusions br Author contributions br Declarations

  2019-08-11

  

  Conclusions Author contributions Declarations of interest Acknowledgments The Radiation Effects Research Foundation (RERF), Hiroshima and Nagasaki, Japan is a public interest foundation funded by the Japanese Ministry of Health, Labour and Welfare (MHLW) and the US Department of Energy (

• br Epigenetic regulation of astrocyte development and functi

  2019-07-30

  

  Epigenetic regulation of astrocyte development and function Conclusion The extent of astrocyte involvement in the development and progression of neurodegenerative diseases is an active area of investigation, particularly following the development of new tools and understanding of reactive astr

• Rats were made hyperammonemic by feeding them

  2019-07-30

  

  Rats were made hyperammonemic by feeding them and ammonium-containing diet [40]. Membrane expression, phosphorylation of the GluA1 and GluA2 subunits and the mechanisms underlying their alterations in hyperammonemic rats were analyzed in freshly isolated cerebellar slices. Material & methods R

• br Transparency document br Introduction The high mortality

  2019-07-24

  

  Transparency document Introduction The high mortality rate of breast cancer (BCa) is mainly due to tumor cell dissemination from the primary lesion, leading to metastatic disease [1]. Metastasis is largely driven by the activity of chemokines, which are chemo-attracting small cytokine molecule

• br Transparency document br Acknowledgements Own research

  2019-07-08

  

  Transparency document Acknowledgements Own research included in this review article was funded by the University Hospital Frankfurt, Frankfurt am Main, Germany and grants of the German Research Foundation (DFG) (CH 806/1-1). Introduction Cholangiocarcinoma (CCA) is the most common biliary

• br Materials and methods br

  2019-07-08

  

  Materials and methods Results Discussion In this study, we demonstrate that SIRT1-mediated deacetylation is required for IPO to activate the Akt signaling pathway to confer cardioprotection. Reduced SIRT1 and increased Akt acetylation are responsible for the loss of IPO-mediated cardioprote

• Variations in DNA repair genes seem to be

  2019-07-06

  

  Variations in DNA repair genes seem to be related to cancer risk; in particular, some studies reported the association between genes in the Omadacycline structure excision repair (BER) pathway, such as 8-oxoguanine DNA glycosylase (OGG1) and apurinic/apyrimidinic endonuclease (APE1/APEX1), and risk

• Important efforts were made during the

  2019-07-06

  

  Important efforts were made during the last decades in order to better understand the key pathogenic features of DR and DN, so that new and more effective therapies and preventative strategies might be developed [[7], [8], [9]]. Despite these, the multifactorial intervention strategies aimed to decr

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